tert-butyl 3-oxospiro[benzofuran-2,4-piperidine]-1-carboxylate
5-chloropyrimidine-2-carbonitrile
CAS: 38275-56-8
Molecular Formula: C5H2ClN3
tert-butyl 3-oxospiro[benzofuran-2,4-piperidine]-1-carboxylate - Names and Identifiers
tert-butyl 3-oxospiro[benzofuran-2,4-piperidine]-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C5H2ClN3 |
| Molar Mass | 139.54 |
| Density | 1.43 |
| Melting Point | 78℃ |
| Boling Point | 292℃ |
| Flash Point | 130℃ |
| Vapor Presure | 0.00189mmHg at 25°C |
| Appearance | Crystalline powder |
| pKa | -4.65±0.22(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.568 |
tert-butyl 3-oxospiro[benzofuran-2,4-piperidine]-1-carboxylate - Introduction
It is an organic compound. Its chemical formula is C6H3ClN3.
In terms of nature, it is a solid substance with a white to light yellow crystalline form. It is almost insoluble in water, but soluble in many organic solvents, such as ethanol, acetone and dimethyl sulfoxide. Its melting point is 84-85°C.
In terms of use, it is an important organic synthesis intermediate. It can be used to synthesize many compounds with biological activity, such as oxalate reductase inhibitors, plant growth regulators and anticancer drugs.
In the preparation method, calcium can be synthesized by the following steps: First, sodium hydrocyanate is added to 5-chloropyrimidine to react to produce 5-chloropyrimidine-2-carbonitrile. Next, by reacting 5-chloropyrimidine-2-carbonitrile with hydrogen chloride under basic conditions, it is obtained.
In terms of safety information, attention should be paid to safe operation because it is an organic cyanide compound. Wear appropriate protective equipment such as protective gloves and goggles during handling and use. In addition, contact with skin and eyes should be avoided, and a well-ventilated working environment should be maintained. If inhaled or ingested, should immediately seek medical treatment.
In terms of nature, it is a solid substance with a white to light yellow crystalline form. It is almost insoluble in water, but soluble in many organic solvents, such as ethanol, acetone and dimethyl sulfoxide. Its melting point is 84-85°C.
In terms of use, it is an important organic synthesis intermediate. It can be used to synthesize many compounds with biological activity, such as oxalate reductase inhibitors, plant growth regulators and anticancer drugs.
In the preparation method, calcium can be synthesized by the following steps: First, sodium hydrocyanate is added to 5-chloropyrimidine to react to produce 5-chloropyrimidine-2-carbonitrile. Next, by reacting 5-chloropyrimidine-2-carbonitrile with hydrogen chloride under basic conditions, it is obtained.
In terms of safety information, attention should be paid to safe operation because it is an organic cyanide compound. Wear appropriate protective equipment such as protective gloves and goggles during handling and use. In addition, contact with skin and eyes should be avoided, and a well-ventilated working environment should be maintained. If inhaled or ingested, should immediately seek medical treatment.
Last Update：2024-04-10 22:30:50
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